Highly Efficient Synthesis of trans-β,γ-Unsaturated α-Keto Amides
نویسندگان
چکیده
منابع مشابه
Efficient synthesis of β’-amino-α,β-unsaturated ketones
A general and simple procedure to access chiral β'-amino-α,β-enones, in seven steps, from an α,β unsaturated ester has been described. The use of a Horner-Wadsworth-Emmons reaction as a key step for generating the β'-amino-α,β-enones, permits access to a range of substrates under mild conditions and in moderate to high yield.
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Carbamoyl anions, generated from N,N-disubstituted formamides and lithium diisopropylamide, add with high diastereoselectivity to chiral N-sulfinyl aldimines and ketimines to provide α-amino amides. The methodology enables the direct introduction of a carbonyl group without the requirement of unmasking steps as with other nucleophiles. The products may be converted to α-amino esters or 1,2-diam...
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A new efficient and highly enantioselective direct asymmetric hydrogenation of α-keto acids employing the Ir/SpiroPAP catalyst under mild reaction conditions has been developed. This method might be feasible for the preparation of a series of chiral α-hydroxy acids on a large scale.
متن کاملCorrection: Copper-catalyzed, hypervalent iodine mediated C=C bond activation of enaminones for the synthesis of α-keto amides.
Correction for 'Copper-catalyzed, hypervalent iodine mediated C=C bond activation of enaminones for the synthesis of α-keto amides' by Jie-Ping Wan et al., Chem. Commun., 2016, 52, 1270-1273.
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ژورنال
عنوان ژورنال: Synthesis
سال: 2009
ISSN: 0039-7881,1437-210X
DOI: 10.1055/s-0029-1216869